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Comparative effects of xenon and nitrous oxide on diaphragmatic contractility in dogs
Author(s) -
Hoshi T.,
Fujii Y.,
Toyooka H.
Publication year - 2002
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1034/j.1399-6576.2002.460611.x
Subject(s) - contractility , medicine , nitrous oxide , xenon , diaphragmatic breathing , anesthesia , diaphragm (acoustics) , inhalation , anesthetic , chemistry , physics , alternative medicine , organic chemistry , pathology , acoustics , loudspeaker
Background: Xenon at two different concentrations (30%, 60%) has no effect on diaphragmatic contractility. This study was undertaken to compare the effects of xenon and nitrous oxide (N 2 O), a commonly used and well‐established gas anesthetic, on diaphragmatic contractility in dogs. Methods: Twenty‐one pentobarbitone‐anesthetized dogs were randomly divided into three groups of seven each: group 1 received xenon 30% (0.25 MAC) in oxygen; group 2 received N 2 O 47% (0.25 MAC) in oxygen; and group 3 received N 2 O 60% (0.32 MAC) in oxygen. Diaphragmatic contractility was assessed by transdiaphragmatic pressure (Pdi) at low‐ (20‐Hz) and high‐frequency (100‐Hz) stimulation, after maintaining 60 min of stable condition. The integrated electrical activity of diaphragm (Edi) to each stimulus was measured. Results: With an inhalation of xenon 30%, N 2 O 47%, or N 2 O 60%, Pdi and Edi at both stimuli did not change. No difference in Pdi or Edi was observed among the groups. Conclusion: When used at clinical concentration, xenon or N 2 O does not affect contractility and electrical activity of the diaphragm in dogs.