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Effect of intravenous prostaglandin E 1 on pial vessel diameters and intracranial pressure in rabbits
Author(s) -
Miyabe M.,
Fukuda T.,
Saito S.,
Tajima K.,
Toyooka H.
Publication year - 2001
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1034/j.1399-6576.2001.451016.x
Subject(s) - medicine , arteriole , intracranial pressure , anesthesia , venule , cerebral blood flow , mean arterial pressure , prostaglandin , perfusion , blood pressure , cerebral perfusion pressure , microcirculation , heart rate
Background: The main advantages of prostaglandin E 1 (PGE 1 ) for induced hypotension during neurosurgery include a rapid onset of action, a quick recovery from hypotension, lack of toxicity, maintenance of adequate perfusion to vital organs, and maintenance of cerebral blood flow reactivity to carbon dioxide during hypotension. However, there is no report that shows the effect of PGE 1 on cerebral microvessel diameter and only a few data are available that show the effect of PGE 1 on intracranial pressure. The aim of this study was to measure cerebral arteriole and venule diameters and intracranial pressure (ICP) during PGE 1 ‐induced hypotension to evaluate whether PGE 1 is suitable for neuroanesthesia. Methods: We measured the effects of 0.1, 0.3, 1.0, 3.0, and 10.0 μg · kg −1 · min −1 of intravenous PGE 1 on mean arterial pressure (MAP), cerebral arteriole and venule diameters and ICP in anesthetized rabbits. Results: MAP decreased statistically significantly from baseline at the infusion rates of 1.0, 3.0, and 10.0 μg · kg −1 · ml −1 . Arteriole diameter increased significantly from the baseline at the infusion rate of 10.0 μg · kg −1 · ml −1 (18% from control). Venule diameter did not change from baseline value at any infusion rate. ICP did not change from baseline value at any infusion rate. Conclusion: We conclude that PGE 1 might be a suitable drug for induced hypotension in neurosurgery from the viewpoint of its small effect on the cerebral microvessels and ICP.