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Comparison of plasma α glutathione S‐transferase concentrations during and after low‐flow sevoflurane or isoflurane anaesthesia
Author(s) -
Higuchi H.,
Adachi Y.,
Wada H.,
Kanno M.,
Satoh T.
Publication year - 2001
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1034/j.1399-6576.2001.451009.x
Subject(s) - sevoflurane , isoflurane , medicine , anesthesia , fresh gas flow , nitrous oxide , glutathione , chemistry , biochemistry , enzyme
Background: We evaluated the effect of low‐flow sevoflurane anaesthesia, in which compound A is generated, and isoflurane anaesthesia, in which compound A is not generated (n=13 in each group), on hepatocellular integrity using α glutathione S‐transferase (GST). α GST is a more sensitive and specific marker of hepatocellular damage than is aminotransferase activity and correlates better with hepatic histology. Methods: Sevoflurane or isoflurane were delivered without nitrous oxide with a fresh gas flow of 1 l/min. Concentrations of compound A in the circuit were measured hourly, and plasma α GST concentrations were measured perioperatively. Results: Mean duration of anaesthesia was 338±92 min in the sevoflurane group and 320±63 min in the isoflurane group. Mean compound A concentration in the sevoflurane group was 28.6±9.0 ppm. There was no significant difference in α GST concentrations between the sevoflurane and isoflurane groups during or after anaesthesia. Conclusion: These results indicate that low‐flow sevoflurane and isoflurane anaesthesia have the same effect on hepatic function, as assessed by plasma α GST concentrations.