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Interactions of halothane with isoproterenol and epinephrine on canine epicardial conduction velocity at normal and elevated potassium levels
Author(s) -
Camara A. K. S.,
Turner L. A.,
Bosnjak Z. J.
Publication year - 2001
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1034/j.1399-6576.2001.045007885.x
Subject(s) - halothane , epinephrine , medicine , nerve conduction velocity , potassium , purkinje fibers , transverse plane , endocrinology , anesthesia , anatomy , electrophysiology , chemistry , organic chemistry
Background: Halothane is known to potentiate catecholamine‐induced depression of conduction velocity in Purkinje fibers but not endocardial muscle fibers. The purpose of this study was to examine the interactions of halothane with epinephrine and isoproterenol on canine epicardial conduction velocity at moderately elevated extracellular potassium concentration ([K] 0 ). Methods: Epicardial muscle strips (10×10×2 mm) were superfused with Tyrode’s solution containing 4 or 8 mM [K] 0 in the presence of 5 μM epinephrine or 1 μM isoproterenol with or without 0.8 mM halothane. Conduction velocity in the longitudinal and transverse directions relative to epicardial fiber orientation was recorded during alternate stimulation in each direction. Results: In the presence of halothane, a change from 4 to 8 mM [K] 0 decreased ( P ≤0.05) longitudinal and transverse conduction velocities by 26% and 21%, respectively. Isoproterenol alone at 4 and 8 mM [K] 0 depressed ( P <0.05) both longitudinal and transverse conduction velocities. However, the depression of longitudinal conduction velocity by isoproterenol at 4 mM [K] 0 was attenuated by halothane. Epinephrine with or without halothane depressed ( P <0.05) both longitudinal and transverse conduction velocities at 8 but not at 4 mM [K] 0 . Conclusion: The results do not support a synergistic interaction between halothane and epinephrine on myocardial conduction but do demonstrate depression of conduction by epinephrine at 8 mM [K + ] 0 , a potassium ion concentration comparable to those reported following epinephrine infusions.