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Time course of changes in jugular venous oxygen saturation during hypothermic or normothermic cardiopulmonary bypass in patients with diabetes mellitus
Author(s) -
Kadoi Y.,
Saito S.,
Goto F.,
Someya T.,
Kamiyashiki S.,
Fujita N.
Publication year - 2001
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1034/j.1399-6576.2001.045007858.x
Subject(s) - medicine , cardiopulmonary bypass , anesthesia , diabetes mellitus , surgery , endocrinology
Background: Preexisting diabetic mellitus is a risk factor determining postoperative neurological disorders. The present study assesses the effects of normothermic and hypothermic cardiopulmonary bypass (CPB) on jugular venous oxygen saturation (SjvO 2 )in patients with preexisting diabetic mellitus. Methods: Sixteen diabetic patients who underwent elective coronary artery bypass grafting surgery were randomly divided into two groups: Group DN (n=8, diabetic patients) underwent normothermic CPB (>35°C), and group DH (n=8, diabetic patients) underwent hypothermic CPB (32°C). Controls were 16 age‐matched non‐diabetic patients (normothemic group, CN: n=8; hypothemic group, CH: n=8). A 4.0 F fiberoptic oximetry oxygen saturation catheter was inserted into the right jugular bulb to continuously monitor SjvO 2 values. Hemodynamic parameters and arterial and jugular venous blood gases were measured seven times. Results: Cerebral desaturation, which was defined as SjvO 2 values below 50%, was observed during normothermic CPB in diabetic patients (at the onset of CPB: 46±3%, at 20 min after onset of CPB: 49±3%, means±SD, respectively). No cerebral desaturation occurred in diabetic and control patients during hypothermic CPB. Conclusions: Patients with preexisting diabetes mellitus experienced cerebral desaturation during normothermic CPB.