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Intrathecal adenosine administration in abdominal hysterectomy lacks analgesic effect
Author(s) -
Rane K.,
Sollevi A.,
Segerdahl M.
Publication year - 2000
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1034/j.1399-6576.2000.440714.x
Subject(s) - medicine , anesthesia , analgesic , fentanyl , hysterectomy , adenosine , visual analogue scale , placebo , saline , isoflurane , abdominal surgery , surgery , alternative medicine , pathology
Background: Adenosine (Ado) is known, from studies in both animals and humans, to produce antinociception when administered systemically or intrathecally (IT). The current aim was to evaluate, in a placebo‐controlled, randomised, double‐blind study, whether IT adenosine given before surgery could reduce anaesthetic requirement and the need of opioids during 48 h after visceral surgery. Method: Forty women (37–66 years, ASA I and II) scheduled for elective hysterectomy were included. Before inducing the standardised O 2 /N 2 O/isoflurane/fentanyl anaesthesia, the patients received an IT injection of either adenosine (500 μg in 1 ml volume) or placebo 1 ml (saline). Intraoperative anaesthetic drug doses and haemodynamics were recorded. Postoperative pain was assessed by visual analogue scale. For postoperative analgesia, cetobemidone was provided via intravenous patient‐controlled analgesia (PCA). Results: During surgery, there were no differences between groups in anaesthetic requirement or haemodynamic parameters. Postoperative cetobemidone requirements were similar in both groups (median 48 mg for adenosine/50 mg for saline) during the first 48 postoperative hours. Conclusion: IT adenosine did not influence the requirement of anaesthetic drug or postoperative analgesics after hysterectomy.