Premium
Comparative effect of amrinone, aminophylline and diltiazem on rat airway smooth muscle
Author(s) -
Matsuda F.,
Sugahara K.,
Sugita M.,
Sadohara T.,
Kiyota T.,
Terasaki H.
Publication year - 2000
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1034/j.1399-6576.2000.440617.x
Subject(s) - amrinone , diltiazem , aminophylline , medicine , inotrope , chronotropic , bronchodilator , anesthesia , bronchodilatation , pharmacology , cardiology , asthma , calcium , heart rate , blood pressure
We investigated the effect of amrinone, a phosphodiesterase III inhibitor, on rat airway smooth muscle, and thereafter, compared its activity with aminophylline and diltiazem. Amrinone produced relaxation of the acetylcholine‐induced airway contraction in a dose‐related manner. This bronchodilatory activity of amrinone was similar to that of aminophylline, but smaller than that of diltiazem. The 50% relaxant effect (ED 50 ) of amrinone, aminophylline and diltiazem were 3.6×10 −4 M, 1.4×10 −4 M and 1.4×10 −5 M, respectively. Diltiazem was the most potent airway relaxant, and amrinone was less potent in these experiments. Taken together in its positive inotropic and chronotropic effects and anti‐inflammatory activity, however, amrinone could be beneficial for treatment of patients suffering from asthma or heart failure with cardiac asthma.