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Intraperitoneal and sigmoid colon tonometry in porcine hypoperfusion and endotoxin shock models
Author(s) -
Koga I.,
Stiernström H.,
Christiansson L.,
Wiklund L.
Publication year - 1999
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1034/j.1399-6576.1999.430703.x
Subject(s) - medicine , saline , perfusion , sigmoid colon , shock (circulatory) , anesthesia , constriction , circulatory system , in vivo , surgery , rectum , microbiology and biotechnology , biology
Background: The objective of the present study was to assess the accuracy of an air tonometry device in vivo within a wide range of regional carbon dioxide tension (PrCO 2 ) values by using saline tonometry as the standard and to investigate the possibilities to monitor perfusion of the intestine by tonometry in the intraperitoneal cavity. Methods: Piglets were anesthetized and mechanically ventilated. A pair of tonometry catheters was placed in the sigmoid colon, while another pair was placed intraperitoneally in the right lower quadrant of the abdomen. Air tonometric regional PCO 2 (aPrCO 2 ) was measured every 15 min intraperitoneally and every 20 min in the sigmoid colon. Saline tonometric measurements were made every 30 min and steady‐state values (ssPrCO 2 ) were derived. Hypoperfusion shock was induced by graded constriction of the aorta. Endotoxin shock was induced by administration of lipopolysaccharide (LPS). Results: The obtained average PrCO 2 (=matched (aPrCO 2 +ssPrCO 2 )/2) values ranged from 5.1 kPa to 14.7 kPa. Regional air PCO 2 (aPrCO 2 ) and steady‐state saline PCO 2 (ssPrCO 2 ) exhibited a strong positive linear relationship (r=0.959). The 95% confidence interval of the mean of dPrCO 2 (=aPrCO 2 −ssPrCO 2 ) was 0.31–0.46 kPa. Intraperitoneal tonometric PrCO 2 was lower than intraluminal PrCO 2 in the sigmoid colon, and was also more sensitive to circulatory changes than sigmoid colon PrCO 2 . Conclusion: The regional air PCO 2 (aPrCO 2 ) showed good agreement with the steady‐state saline regional PCO 2 (ssPrCO 2 ). Intraperitoneal measurements may be an alternative method of monitoring intestinal perfusion after abdominal surgery.