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Investigation of fading responses induced by non‐depolarising muscle relaxants in the evoked EMG of the gastrocnemius muscle of the cat
Author(s) -
Suzuki T.,
Nagai H.,
Katsumata N.,
Ogawa S.,
Suzuki H.
Publication year - 1999
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1034/j.1399-6576.1999.430611.x
Subject(s) - rocuronium , medicine , pancuronium bromide , neuromuscular transmission , fade , neuromuscular blockade , muscle relaxant , neuromuscular monitoring , gastrocnemius muscle , rocuronium bromide , vecuronium bromide , anesthesia , repetitive nerve stimulation , neuromuscular junction , stimulation , acetylcholine , skeletal muscle , myasthenia gravis , neuroscience , propofol , biology , computer science , operating system
Background: During partial neuromuscular blockade indirect repetitive nerve stimulation causes fade in the response of the muscle. We studied the intensity of the fade induced by intravenous administration of three steroidal muscle relaxants, and investigated the mechanism of fade by comparing with results obtained during partial blockade with animal toxins and vesamicol. Methods: In 60 cats, we measured the fade in the compound action potentials of the gastrocnemius muscle evoked by repetitive sciatic nerve stimulation at 100 Hz during partial neuromuscular blockade with rocuronium, vecuronium, pancuronium, α‐bungarotoxin, μ‐conotoxin and vesamicol, respectively. Results: Profound fade was induced by all three non‐depolarising muscle relaxants (rocuronium=vecuronium