Premium
Effects of a leucocyte depleting arterial line filter on perioperative proteolytic enzyme and oxygen free radical release in patients undergoing aortocoronary bypass surgery
Author(s) -
Mair P.,
Hoermann C.,
Mair J.,
Margreiter J.,
Puschendorf B.,
Balogh D.
Publication year - 1999
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1034/j.1399-6576.1999.430414.x
Subject(s) - medicine , extracorporeal circulation , cardiopulmonary bypass , perioperative , malondialdehyde , anesthesia , extracorporeal , arterial line , surgery , oxidative stress
Background: Proteolytic enzymes and oxygen free radicals released from activated leucocytes contribute significantly to the organ dysfunction associated with cardiopulmonary bypass. Leucocyte depletion during extracorporeal circulation should reduce the release of these toxic compounds and thereby improve postbypass myocardial and pulmonary function. Recently, a leucocyte‐specific arterial line filter to achieve leucocyte depletion during clinical perfusion has become commercially available. The aim of this study, therefore, was to evaluate the influence of the leucocyte depleting arterial line filter on proteolytic enzyme release, oxygen free radical release and postbypass pulmonary and myocardial function in patients undergoing bypass surgery. Methods: Forty patients undergoing elective aortocoronary bypass surgery were included into this prospective, randomized clinical study, 20 in the leucocyte depletion (LG‐6 group, leucocyte‐specific arterial line filter) and 20 in the control group (AV‐6 group, standard arterial line filter). White cell count, differential white cell count, plasma elastase concentration, plasma malondialdehyde concentration and C‐reactive protein were determined before, twice during and immediately after cardiopulmonary bypass, at the end of surgery and 6 and 20 h thereafter. Results: White cell count, differential white cell count, malondialdehyde and C‐reactive protein were not significantly different between LG‐6 and control patients. Plasma elastase concentrations were significantly ( P ≤0.03) higher during and immediately after extracorporeal circulation in LG‐6 group patients. Need for inotropic support, arterial pO 2 after extracorporeal circulation and perioperative CK MB mass and troponin I release were not different between the two groups of patients. Conclusion: The use of a leucocyte depleting arterial line filter is associated with an increased release of the proteolytic enzyme elastase, but does not reliably and consistently achieve effective leucocyte depletion during clinical perfusion. In contrast to previous studies, we could not demonstrate any significant difference in postbypass pulmonary or myocardial function between patients perfused with the leucocyte‐specific arterial line filter and control patients. Our data do not support the routine use of a leucocyte depleting arterial line filter during clinical perfusion in patients undergoing elective aortocoronary bypass surgery.