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In vitro effects of propofol on blood coagulability and fibrinolysis by the use of thromboelastograph technique
Author(s) -
Kohro S.,
Yamakage M.,
Omote T.,
Namiki A.
Publication year - 1999
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1034/j.1399-6576.1999.430217.x
Subject(s) - propofol , medicine , fibrinolysis , anesthesia
Background: To investigate the in vitro effects of propofol on blood coagulability and fibrinolysis by the use of thromboelastograph (TEG) technique. Methods: The blood samples, obtained from 14 healthy volunteers, were divided into two groups: propofol (n=7) and intralipid (n=7), and 360 μl volumes of whole blood were incubated with 2 μl of 1% propofol and with its solvent intralipid, respectively. The incubated sample was then used for TEG measurements. Results: The maximum amplitude (MA), which reflects coagulability, in the intralipid group significantly increased by about 7% and 16% compared to the control and propofol groups, respectively ( P <0.05), whereas the MA in the propofol group did not change. The fibrinolytic rate (FR) in the propofol group significantly increased by about 170% and 210% compared to the control and intralipid groups, respectively ( P <0.05), whereas the FR in the intralipid group did not change. Conclusions: Propofol, per se, has at the concentration of 55.6 μg · ml −1 an in vitro accelerative effect on blood fibrinolysis detected by TEG.