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Molecular linkage studies of bipolar disorders
Author(s) -
Berrettini Wade H
Publication year - 2001
Publication title -
bipolar disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.285
H-Index - 129
eISSN - 1399-5618
pISSN - 1398-5647
DOI - 10.1034/j.1399-5618.2001.30603.x
Subject(s) - bipolar disorder , linkage (software) , schizophrenia (object oriented programming) , genetic linkage , genetics , biology , gene , genome , human genome , computational biology , psychology , neuroscience , psychiatry , cognition
Objectives:To review the reports of linkage findings for bipolar disorder.
Methods: Literature review of published linkage findings in bipolar disorder.
Results: There are several regions of the human genome that have been implicated repeatedly by independent investigators. These include 4p16, 12q24, 18q22, 18p11, 21q21 and 22q11. Two of these regions (18p11 and 22q11) are also implicated in genome scans of schizophrenia, suggesting that these two distinct nosological categories may share some genetic susceptibility. This hypothesis can only be tested when the underlying genes are identified.