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Life‐threatening autoimmunity with diabetes: management with an insulin pump
Author(s) -
Franklin V. L.,
Torrance T.,
Peebles M.,
Wilkie R.,
Greene S.
Publication year - 2003
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1034/j.1399-5448.2003.00023.x
Subject(s) - medicine , autoimmunity , enteropathy , type 1 diabetes , immune dysregulation , autoimmune disease , immunology , protein losing enteropathy , diabetes mellitus , autoimmune regulator , disease , autoimmune diabetes , immune system , endocrinology
A 2‐yr‐old boy presented initially with type 1 diabetes (T1D). Over the next 9 yrs, he developed multiple autoimmune conditions including Evans' syndrome, alopecia, and autoimmune bowel disease. Autoimmune polyendocrinopathy, candidiasis, ectodermal dystrophy (APECED) syndrome was considered, but no mutations were found in the autoimmune regulator‐1 ( AIRE‐1 ) gene, making this diagnosis unlikely, and he did not fulfil the clinical criteria for immune dysregulation, polyendocrinopathy, enteropathy, X‐linked (IPEX) syndrome. We describe the challenges created by the combination of these diseases and how introduction of insulin pump therapy revolutionized his care.