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Intramyocellular lipid, adiposity, and muscle oxygen supply in prepubertal type 1 diabetes
Author(s) -
Ling Andrew H.,
Donaghue Kim C.,
Howard Neville J.,
Arrowsmith Fiona E.,
Ward Julie A.,
Baur Louise A.,
Thompson Campbell H.
Publication year - 2003
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1034/j.1399-5448.2003.00021.x
Subject(s) - medicine , endocrinology , type 2 diabetes , diabetes mellitus , glycemic , type 1 diabetes , population , environmental health
Background: In the non‐diabetic population, intramyocellular lipid (IMCL) accumulation is associated with obesity and poor muscle oxygen supply. IMCL levels are increased in type 1 diabetes, but their significance is less clear. Methods: We studied a group of 16 prepubertal boys (age 6.4–9.9 yr) with type 1 diabetes and a range of glycemic control [hemoglobin A1c (HbA1c) 6.4–10.2%]. Children's adiposity was assessed by anthropometry, muscle oxygen supply by near‐infrared spectroscopy (NIRS), abdominal and IMCL content by magnetic resonance imaging (MRI), and magnetic resonance spectroscopy (MRS). Results: IMCL content did not associate with muscle reoxygenation rate, abdominal adiposity, duration of diabetes, or recent glycemic control. Muscle reoxygenation rate correlated with percentage body fatness (r 2 = 0.46, p = 0.004), visceral (r 2 = 0.45, p = 0.007) and abdominal subcutaneous fat volume (r 2 = 0.63, p = 0.0004), and dietary fat intake (r 2 = 0.27, p = 0.03) but not with the duration of diabetes nor HbA1c. HbA1c was significantly related to dietary fat intake only (r 2 = 0.28, p = 0.03). Conclusion: While causality cannot be inferred, interventions aimed at improving muscle oxygen supply, or preventing its deterioration, might reduce the development of adiposity in children with type 1 diabetes.