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Regulation of pancreatic cell differentiation and morphogenesis
Author(s) -
Humphrey Rohan K.,
Smith Murray S.,
Tuch Bernard E.,
Hayek Alberto
Publication year - 2002
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1034/j.1399-5448.2002.30109.x
Subject(s) - foregut , morphogenesis , organogenesis , pancreas , enteroendocrine cell , endocrine system , microbiology and biotechnology , cellular differentiation , germ layer , developmental biology , biology , medicine , pathology , endocrinology , anatomy , embryonic stem cell , genetics , hormone , induced pluripotent stem cell , gene
Organogenesis requires tissue interactions to initiate the cascade of inductive and repressive signals necessary for normal organ development. Tissue interactions initiate the pancreatic lineage within the primitive foregut endodermal epithelium and continue to direct the morphogenesis and differentiation of the endocrine, exocrine and ductal portions of the pancreas. An understanding of the mechanisms controlling pancreatic growth would enable the development of alternative therapies for diseases such as type 1 diabetes.