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Results of crossmatch between chimpanzee lymphocytes and sera of highly sensitized potential renal transplant recipients[Note 1. In memoriam: This work represents an area of active ...]
Author(s) -
Rabkin David G.,
Nowygrod Roman,
Hardy Mark A.,
Reemtsma Keith
Publication year - 2002
Publication title -
xenotransplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.052
H-Index - 61
eISSN - 1399-3089
pISSN - 0908-665X
DOI - 10.1034/j.1399-3089.2002.01108.x
Subject(s) - antibody , immunology , panel reactive antibody , histocompatibility , peripheral blood , renal transplant , medicine , transplantation , antigen , human leukocyte antigen
Background : We tested the hypothesis that patients with a high frequency of lymphocytotoxic antibodies against human cells are not highly sensitized to major histocompatibility complexes expressed by chimpanzee cells. Methods : Sera from six “hopelessly” sensitized patients (percentage reactive antibodies (PRA) > 99%) on the renal transplant waiting list were crossmatched with peripheral blood lymphocytes from 10 chimpanzees. Lymphocytotoxic antibodies reacting with chimpanzee peripheral blood lymphocytes were identified. Results : Three of the six patients with a high frequency of lymphocytotoxic antibodies against human cells had no xenospecific antibodies. Conclusion : Patients with a high frequency of lymphocytotoxic antibodies against human cells are not all panel‐reactive to chimpanzees. Unilateral donor nephrectomy in non‐human primates may offer an opportunity for safe expansion of the donor organ pool for these patients.