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Unusual presentation of herpes virus infections in renal transplant recipients exposed to high mycophenolic acid plasma concentrations
Author(s) -
Smak Gregoor P.J.H.,
Van Gelder T.,
Van Riemsdijkvan Overbeeke I.C.,
Vossen A.C.T.M.,
IJzermans J.N.M.,
Weimar W.
Publication year - 2003
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1034/j.1399-3062.2003.00012.x
Subject(s) - mycophenolic acid , medicine , immunosuppression , renal transplant , mycophenolate , immunology , intensive care medicine , transplantation , gastroenterology
Viral infections constitute an important problem for transplant recipients and their physicians. Often the balance between adequate and over‐immunosuppression is hard to find and therapeutic drug monitoring might be a welcome adjunct in the management of transplant patients. We report four renal transplant recipients with extra‐ordinary presentations of viral disease who were all treated with mycophenolate mofetil and in whom high mycophenolic acid (MPA) trough levels were found. High MPA levels may reflect over‐immunosuppression resulting in infectious complications.