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CMV retinitis after allogeneic bone marrow transplantation: a report of five cases
Author(s) -
Larsson K.,
Lönnqvist B,
Ringdén O,
Hedquist B,
Ljungman P,
Larsson K.,
Lönnqvist B.,
Ringdén O.,
Hedquist B.,
Ljungman P.
Publication year - 2002
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1034/j.1399-3062.2002.01018.x
Subject(s) - medicine , retinitis , complication , cytomegalovirus retinitis , cytomegalovirus , transplantation , sibling , stem cell , human cytomegalovirus , surgery , betaherpesvirinae , bone marrow , immunology , viral disease , herpesviridae , human immunodeficiency virus (hiv) , virus , psychology , developmental psychology , biology , genetics
Four cases of cytomegalovirus (CMV) retinitis (CMVR) after allogeneic blood stem cell transplant (SCT) were documented in Huddinge University Hospital between 1994 and 1999. Prior to 1994, only one case was documented. All five patients were transplanted due to malignant disease, two with sibling donors and three with matched unrelated donors. Despite adequate antiviral treatment against CMV retinitis, the result has been almost total unilateral blindness in three patients. However rare, the complication seems to have become more common since we began doing more matched unrelated donor transplants, which leads to a more pronounced T‐cell defect and to a delayed immune reconstitution compared to sibling transplants. We conclude that CMV retinitis is a rare but important complication to allogeneic blood stem cell transplantation.