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NF‐κB in transplantation: friend or foe?
Author(s) -
Tsoulfas George,
Geller David A.
Publication year - 2001
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1034/j.1399-3062.2001.30405.x
Subject(s) - medicine , tacrolimus , nf κb , immunosuppression , transcription factor , sepsis , signal transduction , transplantation , immune system , organ transplantation , immunology , reperfusion injury , nfkb1 , gene , inflammation , ischemia , microbiology and biotechnology , biology , genetics
NF‐κB is an inducible nuclear transcription factor regulating the expression of many genes. NF‐κB activation may function as a master switch in a variety of immune and inflammatory processes, including sepsis and transplant tolerance. In this review, we summarize features of NF‐κB regulation, as well as describe its role in intracellular signal transduction pathways. Subsequently, we concentrate on the role of NF‐κB in the field of organ transplantation and the role of NF‐κB in organ ischemia/reperfusion injury and graft rejection. Finally, potential therapeutic strategies are discussed to modify NF‐κB activity with certain immunosuppression medications, including cyclosporine, tacrolimus, and glucocorticoids.