Premium
Recurrent Epstein–Barr virus associated disease in a cardiac transplant patient: evolution from plasmacytic hyperplasia to diffuse large cell lymphoma
Author(s) -
Larratt L.M.,
Hamilton M.,
Coupland R.,
Preiksaitis J.K.
Publication year - 2001
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1034/j.1399-3062.2001.003002119.x
Subject(s) - medicine , lymphoma , hyperplasia , diffuse large b cell lymphoma , disease , pathology , epstein–barr virus , virus , lymphoid hyperplasia , immunology
An Epstein–Barr virus (EBV)‐seronegative 31‐year‐old male underwent cardiac transplantation in 1991 for congenital cardiomyopathy. He presented with a protracted course of waxing and waning lymphadenopathy beginning four years after transplantation with eventual progression to a fulminant EBV‐positive large cell lymphoma eight years after transplantation. Risk factors for the development of post‐transplant lymphoproliferative disease in this patient, the importance of a standardized approach to pathology in assessing therapeutic options, and the management strategies used are discussed.