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Cytomegalovirus maculopapular eruption in a kidney transplant patient
Author(s) -
Trimarchi Hernán,
Casas Gabriel,
Jordan Rosana,
Martínez Jorge,
Schropp Juan,
Freixas Emilio Ar,
Efrón Ernesto
Publication year - 2001
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1034/j.1399-3062.2001.003001047.x
Subject(s) - medicine , ganciclovir , maculopapular rash , kidney transplantation , transplantation , asymptomatic , rash , pneumonitis , cytomegalovirus , skin biopsy , dermatology , biopsy , surgery , pathology , immunology , human cytomegalovirus , viral disease , virus , herpesviridae , lung
Cytomegalovirus (CMV) is the most important viral agent in kidney transplantation. Clinical manifestations of CMV disease in transplantation include hepatitis, pneumonitis, pancreatitis, kidney allograft dysfunction, colitis, and meningoencephalitis. However, skin involvement is rare. We describe a severely compromised cadaveric‐kidney transplant recipient who developed renal failure, colonic ulcers, and a maculopapular rash accompanied by fever and malaise 4 months after transplantation. Only the skin biopsy was diagnostic and consistent with CMV disease. Intravenous ganciclovir administration resulted in clinical improvement of CMV‐induced skin lesions; kidney function normalized and the patient became asymptomatic after 14 days of ganciclovir therapy. Nephrologists should consider the diagnosis of CMV disease in the febrile immunosuppressed patient with skin involvement. Skin biopsy must be considered as a useful and safe procedure in patients with a rash to obtain a prompt diagnosis and efficiently treat this immunocompromised population.