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Cytomegalovirus prophylaxis with ganciclovir and cytomegalovirus immune globulin in liver and intestinal transplantation
Author(s) -
Tzakis A.G.
Publication year - 2001
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1034/j.1399-3062.2001.00007.x
Subject(s) - medicine , ganciclovir , cytomegalovirus , immunosuppression , immunology , liver transplantation , regimen , gastroenterology , transplantation , population , herpesviridae , virus , human cytomegalovirus , viral disease , environmental health
Liver and intestinal transplant recipients at the University of Miami receive an intensive regimen of cytomegalovirus (CMV) prophylactic therapy consisting of a combination of CMV immune globulin intravenous (CMV‐IGIV, CytoGam®) and ganciclovir. The 5‐year experience with this regimen in liver transplant patients showed effective CMV prophylaxis in this patient population. The importance of an effective prophylactic strategy was underscored by higher observed rates of chronic rejection and post‐transplant lymphoproliferative disorder (PTLD) in CMV‐infected patients. The use of CMV‐positive donors for intestinal transplants did not increase the incidence of CMV disease. Intestinal transplant recipients had improved survival rates, reflecting an aggressive policy of monitoring, immunosuppression, and CytoGam® plus ganciclovir prophylaxis.