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Bone marrow transplantation: it's not just about blood anymore!
Author(s) -
Horwitz Edwin M.
Publication year - 2003
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1034/j.1399-3046.7.s3.8.x
Subject(s) - mesenchymal stem cell , medicine , bone marrow , stem cell , transplantation , haematopoiesis , stem cell transplantation for articular cartilage repair , clinical uses of mesenchymal stem cells , hematopoietic stem cell , hematopoietic stem cell transplantation , stem cell therapy , pathology , adult stem cell , cancer research , endothelial stem cell , surgery , biology , microbiology and biotechnology , in vitro , biochemistry
Bone marrow transplantation is established as effective cell therapy for hematopoietic disorders. With the recognition that bone marrow also contains mesenchymal stem cells, with the potential to differentiate to a wide variety of mesenchymal tissues, bone marrow transplantation, in theory, may be used to treat many nonhematopoietic disorders as well. Here, we present an overview of the developments of clinically oriented marrow mesenchymal stem cell biology and it's early applications as adjunct cell therapy in conventional stem cell transplantation, and most importantly as stem cell therapy for nonhematopoietic disorders.