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Megadose transplantation of highly purified haploidentical stem cells: current results and future prospects
Author(s) -
Handgretinger Rupert,
Klingebiel Thomas,
Lang Peter,
Gordon Paul,
Niethammer Dietrich
Publication year - 2003
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1034/j.1399-3046.7.s3.7.x
Subject(s) - medicine , stem cell , transplantation , cd34 , haematopoiesis , hematopoietic stem cell transplantation , positive selection , immunology , cancer research , microbiology and biotechnology , biology , gene , genetics
The transplantation of megadoses of haploidentical hematopoietic stem cells is for a number of children with malignant or nonmalignant diseases the only curative approach. In order to prevent severe GvHD, the removal of T lymphocytes from the stem cell graft either by positive selection of CD34 + stem cells or by negative depletion of CD3 + T lymphocytes is necessary. We present the results obtained so far by CD34 + positive selection and discuss new techniques of graft engineering which might hopefully further improve the outcome of haploidentical stem cell transplantation.