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Induction of a transient graft vs. leukemia effect following unrelated cord blood transplantation
Author(s) -
Haut Paul R.,
GonzalezRyan Lydia,
Wang LingJia,
Olszewski Marie,
Morgan Elaine,
Kletzel Morris
Publication year - 2002
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1034/j.1399-3046.2002.00215.x
Subject(s) - medicine , umbilical cord , leukemia , transplantation , minimal residual disease , cord blood , immunology , haematopoiesis , hematopoietic stem cell transplantation , stem cell , acute leukemia , umbilical cord blood transplantation , graft versus host disease , disease , lymphoblastic leukemia , biology , genetics
Umbilical cord blood (UCB) has become a frequent source of allogeneic hematopoietic stem cells for transplantation. Of theoretical concern is a potential decrease in the graft vs. leukemia (GvL) effect, given the lesser degree of graft vs. host disease (GvHD) with this donor source. We report a case of recurrent acute non‐lymphoblastic leukemia (ANLL) following stem cell transplantation with unrelated mismatched UCB, which responded to the induction of GvHD. The response was documented both morphologically and by evaluation of chimeric engraftment by molecular DNA techniques. In addition, WT‐1, a purported marker of minimal residual disease in acute leukemia, correlated with remission status in this patient. In summary, the GvL effect is seen with allogeneic UCB transplantation and has the potential to be induced along with GvHD.