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Elevated tacrolimus trough levels in association with mycophenolate mofetil‐induced diarrhea: A case report
Author(s) -
Frühwirth M.,
Fischer H.,
Simma B.,
Ellemunter H.
Publication year - 2001
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1034/j.1399-3046.2001.005002132.x
Subject(s) - medicine , tacrolimus , mycophenolate , diarrhea , trough level , immunosuppression , mycophenolic acid , kidney transplantation , trough (economics) , trough concentration , gastroenterology , pharmacokinetics , transplantation , urology , economics , macroeconomics
The combination of tacrolimus (TAC) and mycophenolate mofetil (MMF) is frequently used for immunosuppression after organ transplantation (Tx), but the pharmacokinetics and interactions between the two drugs are poorly elucidated. We describe here the increase of TAC trough levels during MMF‐induced diarrhea in a 8‐yr‐old boy after kidney Tx. Early dose reduction of TAC, together with short‐term monitoring of TAC trough levels in the presence of diarrhea, is recommended.