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The management of Epstein–Barr virus associated post‐transplant lymphoproliferative disorders in pediatric solid‐organ transplant recipients
Author(s) -
Green Michael,
Michaels Marian G.,
Webber Steven A.,
Rowe David,
Reyes Jorge
Publication year - 1999
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1034/j.1399-3046.1999.00066.x
Subject(s) - medicine , lymphoproliferative disease , lymphoproliferative disorders , organ transplantation , epstein–barr virus , immunology , post transplant lymphoproliferative disorder , transplantation , virus , complication , disease , intensive care medicine , pathology , lymphoma
Despite a growing understanding of the pathogenesis and spectrum of Epstein–Barr virus (EBV) and EBV‐associated post‐transplant lymphoproliferative disease (PTLD) in organ transplant recipients, the optimal management of this complication remains controversial. The absence of comparative data evaluating potential therapeutic strategies explains the lack of uniformly accepted guidelines for the management of PTLD. The purpose of this review is to provide an overview of potential therapies and offer a set of guidelines for the management of EBV‐associated PTLD in children.