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Mobilization/harvest and transplantation with blood stem cells, manipulated or unmanipulated
Author(s) -
Kawano Yoshifumi,
Watanabe Tsutomu,
Takaue Yoichi
Publication year - 1999
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1034/j.1399-3046.1999.00049.x
Subject(s) - medicine , apheresis , stem cell , peripheral blood stem cells , haematopoiesis , transplantation , bone marrow , surgery , hematopoietic stem cell transplantation , peripheral blood , hematopoietic stem cell , chemotherapy , platelet , oncology , intensive care medicine , immunology , genetics , biology
Collection of peripheral blood stem cells (PBSC) is very feasible without the risk of anesthesia or invasive multiple bone marrow aspirations, because it can be accomplished by modification to the standard apheresis techniques that are routinely used at blood centers for the collection of single donor platelets. Use of PBSC results in rapid and durable trilineage hematopoietic recovery after myeloablative chemotherapy. There has been increasing development in technology for cell processing (‘graft engineering’), moving from the experimental to the clinical settings. Although peripheral blood stem cell transplantation (PBSCT) makes ‘cell component therapy’ far more effective than bone marrow transplantation, its advantages/disadvantages still need to be clarified in children. The following paper presents our pediatric experience of PBSCT.