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The potential role of rapamycin in pediatric transplantation as observed from adult studies
Author(s) -
Kahan Barry D.
Publication year - 1999
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1034/j.1399-3046.1999.00036.x
Subject(s) - medicine , transplantation , medline , intensive care medicine , surgery , political science , law
Kahan BD. The potential role of rapamycin in pediatric transplantation as observed from adult studies. Pediatr Transplantation 1999: 3: 175–180. © Munksgaard, 1999 Abstract: Although pediatric patient and renal graft survival rates have shown marked improvements during the past decade, the persistent toxicities of immunosuppressive drugs and chronic allograft attrition remain major obstacles in transplant therapy. Results in adult patients suggest that complete steroid withdrawal is possible in the majority of recipients under treatment with a cyclosporin A–rapamycin (CsA–RAPA) regimen. Furthermore, preliminary studies suggest that a marked reduction in the dose of CsA may be possible under the umbrella of RAPA coverage. The gain in immunosuppressive efficacy afforded by RAPA has not only been obtained without an increased morbidity owing to infectious or neoplastic causes, but also with the potential for reducing the incidence and/or progression of chronic rejection.