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Plasmapheresis, intravenous cytomegalovirus‐specific immunoglobulin and reversal of antibody‐mediated rejection in a pediatric renal transplant recipient: A case report
Author(s) -
Furth S.,
Neu A. M.,
Hart J.,
Zachary A.,
Colombani P.,
Fivush B. A.
Publication year - 1999
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1034/j.1399-3046.1999.00022.x
Subject(s) - medicine , plasmapheresis , cytomegalovirus , immunology , antibody , panel reactive antibody , human leukocyte antigen , monoclonal antibody , intravenous immunoglobulin therapy , kidney transplantation , transplantation , antigen , herpesviridae , virus , viral disease
This is a pediatric case report illustrating the development of antibody (Ab)‐mediated rejection in a patient with low levels of pretransplant anti‐human leucocyte antigen (HLA) panel reactive antibodies (PRA). The clinical course of this patient suggests that aggressive use of a combination of plasmapheresis, monoclonal anti‐T‐lymphocyte antibody therapy, and intravenous immunoglobulin (IVIG) therapy can reverse Ab‐mediated rejection in previously allosensitized pediatric transplant recipients.