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The apo A‐I gene promoter region polymorphism determines the severity of hyperlipidemia after heart transplantation
Author(s) -
GonzálezAmieva Angel,
LópezMiranda José,
Marín Carmen,
PérezMartinez Pablo,
Gómez Purificación,
PazRojas Elier,
Arizón Josè M.,
JiménezPerepérez José A.,
Concha Manuel,
PérezJiménez Francisco
Publication year - 2003
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1034/j.1399-0012.2003.02038.x
Subject(s) - triglyceride , hyperlipidemia , medicine , genotype , apolipoprotein b , transplantation , heart transplantation , endocrinology , cholesterol , lipid profile , gastroenterology , biology , genetics , gene , diabetes mellitus
Background: To study whether the Apolipoprotein A‐I (apo A‐I) promoter region gene polymorphism produces changes in the lipid profile of heart transplant recipients. Methods: One hundred and three heart transplant recipients (93 men and 10 women, with a mean age of 47 ± 13 yr) receiving triple immunosuppressive therapy were submitted to a genetic study of the apo A‐I gene promoter region. Anthropometric and analytical data, including lipid profile, arterial blood pressure, were collected prior to transplantation and 3, 6, 12, and 24 months after transplantation. Results: Sixty‐three subjects had the GG genotype and 40 the GA genotype. Carriers of the GA genotype had higher triglyceride levels at 6 months and 2 yr (2.50 ± 1.20 versus 1.93 ± 0.98 mmol/L and 2.46 ± 1.58 versus 1.60 ± 0.68 mmol/L, respectively, p < 0.001), and a greater rise in LDL‐cholesterol at 1 yr than the GG subjects (4.57 ± 1.16 versus 4.16 ± 1.18 mmol/L, p < 0.05). Multiple regression analyses showed that genetic variants at the apo A‐I promoter region are responsible for 11% of the variability in triglyceride levels at 6 months (p = 0.005). Conclusions: The GA genotype of the apo A‐I promoter region produces a greater rise in plasma triglyceride and LDL‐cholesterol levels in heart transplant patients.