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Human Herpesvirus 8 and Epstein–Barr virus‐related monotypic large B‐cell lymphoproliferative disorder coexisting with mixed variant of Castleman's disease in a lymph node of a renal transplant recipient
Author(s) -
Theate Ivan,
Michaux Lucienne,
Squifflet JeanPaul,
Martin Antoine,
Raphael Martine
Publication year - 2003
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1034/j.1399-0012.2003.00098.x
Subject(s) - medicine , castleman disease , lymphoproliferative disorders , epstein–barr virus , immunosuppression , herpesviridae , virus , lymph node , pathology , lymphoma , gammaherpesvirinae , immunology , virology , disease , viral disease
Human herpesvirus 8 (HHV8) has been related to some malignant lymphoproliferations, including post‐transplant lymphoproliferative disorders (PTLD). We describe a case of a HHV8 and Epstein–Barr virus (EBV) positive large B‐cell lymphoproliferation coexisting with Castleman's disease in the same lymph node of a long‐term renal transplant recipient. Biopsy revealed mixed type of Castleman's disease and anaplastic cells showing IgA restriction, although molecular analysis failed to detect monoclonality. Only large cells were co‐infected by both EBV and HHV8. After reduction of immunosuppression, the lesion partially regressed. After 1 yr, local evolution required surgery followed by irradiation. The present case represents a unique form of localized monotypic but polyclonal large cell PTLD associated with Castleman's disease. It can be added to PTLD with HHV8 and EBV co‐infection.