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Malignancies after heart transplantation: presence of Epstein–Barr virus and cytomegalovirus
Author(s) -
Mattila Petri S,
Aalto Sanna M,
Heikkilä Lasse,
Mattila Severi,
Nieminen Markku,
Auvinen Eeva,
Hedman Klaus,
Tarkkanen Jussi
Publication year - 2001
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1034/j.1399-0012.2001.150506.x
Subject(s) - medicine , cytomegalovirus , epstein–barr virus , malignancy , virus , transplantation , herpesviridae , heart transplantation , betaherpesvirinae , lymphoma , human cytomegalovirus , gammaherpesvirinae , immunology , viral disease , polymerase chain reaction , virology , pathology , biology , gene , biochemistry
The presence of Epstein–Barr virus (EBV), human papilloma virus (HPV), and cytomegalovirus (CMV) was studied in 20 patients who developed malignancies after heart transplantation in the Helsinki University Central Hospital. The tumors were analyzed for the presence of HPV by polymerase chain reaction and for EBV by in situ hybridization. Clinical CMV infection was verified by immunochemical quantitation of CMV antigen in peripheral blood cells. HPV was detected in one of the eight epithelial malignant tumors studied. Three of the six lymphomas were positive for EBV. Two (67%) of 3 patients with EBV‐positive lymphomas and one (33%) of the other three lymphomas but only 2 (14%) of 14 patients who developed other malignancies had a history of a manifest post‐transplantation CMV infection prior to the development of malignancy. These results confirm the presence of EBV in lymphomas of heart transplant recipients and suggest that CMV might have a contributory role in the development of EBV‐associated lymphomas.