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A peculiar vacuolization in the kidney transplant of a child treated with tacrolimus
Author(s) -
Watanabe Seiji,
Yamaguchi Yutaka,
Hattori Motoshi,
Chikamoto Hiroko,
Matsumoto Naoko,
Suzuki Toshiaki,
Oonishi Makiko,
Horita Shigeru,
Tokumoto Tadahiko,
Tanabe Kazunari,
Shiraga Hiroshi,
Toma Hiroshi,
Ito Katsumi
Publication year - 2000
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1034/j.1399-0012.2000.0140s3030.x
Subject(s) - vacuolization , nephrotoxicity , medicine , tacrolimus , pharmacokinetics , kidney , urology , biopsy , bioavailability , pharmacology , transplantation
Tacrolimus (TAC) is a useful immunosuppressive agent in the prevention of rejection. However, the blood level between its therapeutic and toxic levels is narrow such that its nephrotoxicity is a problem. Moreover, its bioavailability and pharmakokinetics are highly variable. We experienced a case of acute nephrotoxicity, in which the blood level rose about 10 times above the expected level. We found a peculiar vacuolization in the transplant biopsy specimen. This change showed a marked vacuolization of the tubular cells, suggestive of acute nephrotoxicity by TAC.