Premium
Adhesion molecules in patients after lung transplantation
Author(s) -
Bewig B,
Tiroke A,
Böttcher H,
Padel K,
Hirt S,
Haverich A,
Cremer J
Publication year - 1999
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1034/j.1399-0012.1999.130510.x
Subject(s) - bronchoalveolar lavage , medicine , cd18 , transplantation , lung transplantation , cd11a , cd11c , integrin alpha m , lung , intercellular adhesion molecule 1 , immunology , cell adhesion molecule , complication , pathology , immune system , biology , phenotype , biochemistry , gene
Leukocyte adhesion molecules, such as intercellular adhesion molecule (ICAM)‐1 and its ligands, are involved in inflammatory processes of the lung. For ICAM‐1, differential expression during different kinds of complications after transplantation has been proposed. We analyzed the role of ICAM‐1, CD18, CD11a, CD11b, and CD11c during episodes of rejection or infection in patients after lung transplantation and compared the results to episodes without apparent complication. A total of 98 bronchoalveolar lavage (BAL) samples and 90 serum samples were analyzed. ICAM‐1, CD18, CD11a, CD11b, and CD11c expressions were detected immunocytochemically on alveolar macrophages. Soluble ICAM‐1 was quantified in serum and BAL. In the control group, 49.8±18% of macrophages stained positive for CD11b. During rejection, the mean of cells showing CD11b on the surface was significantly higher (64.6±11.4%), with no difference compared to episodes of infection (59.7±22.7). All other epitopes were not expressed differently with regard to a normal clinical course or episodes of infection and rejections. In summary, assessment of ICAM‐1 and corresponding ligands did not allow for a reliable discrimination between episodes of rejection or infection in lung transplantation.