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A case report of a renal transplant recipient developing chronic glomerular rejection with a weak antibody against anti‐donor T‐cell, only detected by flow‐cytometry crossmatch
Author(s) -
Takeda Asami,
Uchida Kazuharu,
Haba Toshihito,
Tominaga Yoshihiro,
Katayama Akio,
Gotoh Norihiko,
Otsuka Yasuhiro,
Fukuda Michio,
Horike Keiji,
Shimano Yasunobu,
Takeuchi Oki,
Yoshida Atsuhiro,
Oikawa Tadashi,
Morozumi Kunio
Publication year - 2003
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1034/j.1399-0012.17.s10.4.x
Subject(s) - medicine , pathogenesis , peritubular capillaries , flow cytometry , antibody , immunology , pathology , renal biopsy , kidney transplantation , biopsy , transplantation
The pathogenesis of antibody‐mediated rejection has been investigated, but the precise mechanism of chronic glomerular rejection remains unclear. We have followed the clinicopathological course of a patient with pre‐existing anti‐donor antibody only detected by flow‐cytometry crossmatch for over 3 years. Glomerular endothelial injuries and peculiar glomerular lesions were noted in biopsy specimen of postoperative year 3; however, both typical chronic vascular rejection lesions and peritubular capillary multilayered lesions were not revealed. We consider that the presence of weak anti‐donor antibody leading early onset of acute humoral rejection played a role in the pathogenesis of early onset of chronic transplant glomerulopathy.