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Cholesterol ester transfer protein, apolipoprotein E and lipoprotein lipase genotypes in patients with coronary artery disease in the Turkish population
Author(s) -
Isbir T,
Yilmaz H,
Agachan B,
Karaali ZE
Publication year - 2003
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1034/j.1399-0004.2003.00137.x
Subject(s) - cholesterylester transfer protein , turkish population , medicine , allele , lipoprotein lipase , apolipoprotein b , genotype , endocrinology , coronary artery disease , biology , cholesterol , lipoprotein , allele frequency , population , apolipoprotein e , genetics , gene , disease , adipose tissue , environmental health
The aim of this study was to compare patients with coronary artery disease (CAD) to healthy objects, in order to explore a possible association between CAD and the variants in the gene encoding cholesterol ester transfer protein (CETP), apolipoprotein E (Apo E) and lipoprotein lipase (LPL). The relationship between CETP MspI, apo E and LPL PvuII gene polymorphisms and serum lipids were investigated in 173 patients with CAD and 111 healthy controls. The frequency of Apo ε4 (p < 0.05) and CETP M1 (p < 0.01) alleles were higher in the CAD group than in the control group. In the CAD group, those with the Msp M1 allele had higher levels of total cholesterol (TC) (p = 0026) and low‐density lipoprotein cholesterol (LDL‐C) than those with the Msp M2 allele. Subjects with an ε2 allele had the lowest levels of TC and LDL‐C, while subjects with the ε4 allele had the highest. In the control group, CETP, the Msp M2 allele was associated with a higher level of high‐density lipoprotein cholesterol (HDL‐C) (p = 0.012) than the Msp M1 allele. The distributions of LPL genotype and allele did not differ between the CAD and control groups. The present study demonstrates that the CETP Msp1 and Apo E gene polymorphisms are associated with variations in lipids in patients with CAD and healthy controls in Turkish population.