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Tremor, ataxia and dementia in older men may indicate a carrier of the fragile X syndrome
Author(s) -
Rogers C,
Partington MW,
Turner GM
Publication year - 2003
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1034/j.1399-0004.2003.00089.x
Subject(s) - fragile x syndrome , dementia , ataxia , atrophy , fragile x , medicine , pediatrics , psychology , psychiatry , audiology , genetics , disease , biology , gene
Recently it has been reported that late‐onset tremor, gait unsteadiness and dementia can be associated with brain atrophy in males of normal intelligence and the pre‐mutation carrier state of the fragile X syndrome. We have shown, by means of a telephone survey, that this association is probably causal rather than coincidental. These findings have uncovered another testable cause of late‐onset neurological symptoms in males, which also has serious genetic implications for their daughters who are at risk of having sons with full mutations causing mental handicap – the fragile X syndrome.