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Homologous telomere association of 19q in a female with premature ovarian failure
Author(s) -
Zahed L,
Darwiche N,
Batanian JR,
Awwad J
Publication year - 2002
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1034/j.1399-0004.2002.620410.x
Subject(s) - premature ovarian failure , telomere , biology , chromosome , chromosome instability , genetics , homologous chromosome , peripheral blood , genome instability , medicine , dna , endocrinology , dna damage , immunology , gene
Premature ovarian failure (POF) may be due to a variety of genetic mechanisms. We report here, for the first time, telomere association of the long arms of chromosome 19, identified at low frequency (1%) in the peripheral blood cultures of a 30‐year‐old female with POF. Repeat cultures identified, in addition, the presence of 16q and 22q associations at a lower frequency (0.5%). These consistent observations are suggestive of a non‐random event. Their association with POF may just be coincidental or may hypothetically explain it by an abnormal mechanism of chromosome separation, a constitutional telomere anomaly or an unidentified chromosome instability disorder.