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Interdependent effect of angiotensin‐converting enzyme and platelet‐activating factor acetylhydrolase gene polymorphisms on the progression of immunoglobulin A nephropathy
Author(s) -
Yoon HJ,
Kim H,
Kim HL,
Lee SG,
Zheng SH,
Shin JH,
Lim CS,
Kim S,
Lee JS,
Lee DS,
Kim YS
Publication year - 2002
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1034/j.1399-0004.2002.620205.x
Subject(s) - allele , nephropathy , odds ratio , genotype , angiotensin converting enzyme , medicine , endocrinology , gene polymorphism , biology , immunology , genetics , gene , blood pressure , diabetes mellitus
In order to investigate the interdependent action of the insertion/deletion polymorphism of the angiotensin‐converting enzyme (ACE) gene and polymorphism in exon 11 (C1136→T; Ala379Val) of the platelet‐activating factor acetylhydrolase (PAF‐AH) gene, which encodes a functional antagonist of PAF, on the progression of immunoglobulin A (IgA) nephropathy, we analysed both polymorphisms in patients with primary IgA nephropathy, who were followed‐up for longer than 3 years. During the follow‐up (87.3 ± 50.0 months), the disease progressed in 38 of the 191 patients (19.9%). The D allele of the ACE gene in the absence of the T allele of the PAF‐AH gene did not affect the prognosis [odds ratio (OR), 3.6; 95% confidence interval (CI), 0.8–16.4] and neither did the T allele in the absence of the D allele (OR, 3.0; 95% CI, 0.4–24.2). However, the presence of both was a significant prognostic factor (OR, 6.6; 95% CI, 1.4–31.3). After adjusting for other risk factors, the presence of both proved to be an independent risk factor (OR, 4.5; 95% CI, 1.6–12.7). These results suggest that the interdependent effects of ACE and PAF‐AH polymorphisms on the progression of IgA nephropathy might be more important than the effect of the individual polymorphisms.