Premium
A patient with treatment‐resistant schizophrenia and cytochrome P4502D6 gene duplication
Author(s) -
Kawanishi C,
Furuno T,
Kishida I,
Matsumura T,
Kosaka K
Publication year - 2002
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1034/j.1399-0004.2002.610211.x
Subject(s) - gene duplication , cyp2d6 , gene , schizophrenia (object oriented programming) , genetics , mutation , medicine , biology , psychiatry , genotype
We describe a patient with treatment‐resistant schizophrenia who had a duplication in the cytochrome P450IID6 (CYP2D6) gene. This severely ill 71‐year‐old‐woman had responded poorly to several neuroleptics. Molecular genetic study revealed CYP2D6 gene duplication, which results in excessive activity of CYP2D6 that metabolizes various commonly used neuroleptics. The mutation may have contributed to treatment resistance in this case.