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Apolipoproteins AI, B, and E polymorphisms in severe aortic valve stenosis
Author(s) -
Avakian SD,
AnnicchinoBizzacchi JM,
Grinberg M,
Ramires JAF,
Mansur AP
Publication year - 2001
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1034/j.1399-0004.2001.600511.x
Subject(s) - medicine , apolipoprotein b , aortic valve , aortic valve stenosis , body mass index , stenosis , genotype , cardiology , endocrinology , allele , univariate analysis , lipoprotein , low density lipoprotein , cholesterol , biology , genetics , gene , multivariate analysis
Hypercholesterolemia has been related to aortic valve stenosis (AS). Polymorphisms of apolipoproteins (apo) AI, B, and E are associated with variable levels of plasma lipids, but the association between these polymorphisms and AS is unknown. In a case–control study of groups matched by age, sex, comparable body mass index, hypertension, triglycerides, high‐density lipoprotein (HDL) cholesterol, and low‐density lipoprotein (LDL) cholesterol, we analyzed the distribution of apo AI A/G mutation, apo B signal peptide insertion/deletion, apo B Xba I restriction fragment length, and apo E polymorphisms in 62 non‐diabetic patients with severe aortic valve stenosis and 62 control subjects. All patients underwent echocardiographic analysis. Univariate analysis showed a higher prevalence of the Xba I X+/X+ genotype (p=0.007) of apo B and the apo E2 allele (p=0.034) in patients with severe AS. Apo polymorphisms were not associated with lipid levels, left ventricular mass, or the aortic gradient.