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Apolipoprotein E polymorphism and lipid levels differ by gender and family history of diabetes: the Rancho Bernardo Study
Author(s) -
Oh JY,
BarrettConnor E
Publication year - 2001
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1034/j.1399-0004.2001.600207.x
Subject(s) - family history , diabetes mellitus , dyslipidemia , medicine , endocrinology , apolipoprotein e , waist , type 2 diabetes , obesity , disease
Association between apolipoprotein E (apoE) gene polymorphism and lipid levels was studied in 164 nondiabetic first‐degree relatives of persons with diabetes and 962 nondiabetic persons with no family history of diabetes. Sex‐specific genotypic distribution of apoE polymorphism did not differ between persons with and without a family history of diabetes. In first‐degree relatives, lipid levels did not differ among persons with apoE2 (E2/2, E2/3), apoE3/3, and apoE4 (E4/4, E3/4) after adjusting for age, waist circumference, smoking, and alcohol and estrogen use. In persons without a family history of diabetes, both men (p<0.01) and women (p<0.001) with apoE2 showed lower levels of total and low density lipoprotein cholesterol compared with persons with apoE3/3 and apoE4. In women with a family history of diabetes, persons with apoE4 had larger waist circumference (p<0.05). ApoE2 allele is associated with more favorable levels of total and low density lipoprotein cholesterol in men and women without a family history of diabetes. ApoE4 allele is associated with obesity independent of dyslipidemia in women but not men with a family history of diabetes. ApoE polymorphism is not associated with lipids in men or women with a family history of diabetes.