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Factors influencing sib risks for Multiple Sclerosis
Author(s) -
Sadovnick AD,
Yee IML,
Ebers GC
Publication year - 2000
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1034/j.1399-0004.2000.580602.x
Subject(s) - trait , multiple sclerosis , genetics , biology , genetic predisposition , candidate gene , gene , computer science , immunology , programming language
Multiple sclerosis (MS) is now thought to be a complex trait determined by genetic and non‐genetic (environmental) factors.
The study group, identified from the Canadian Collaborative Project on Genetic Susceptibility to MS, consisted of 1 083 MS index cases, 2 166 of their parents and 3 112 of their sibs. The results, together with those of a previous study on an independent data set, suggest that gender, age of MS onset and having one parent with MS may individually and interactively alter sib risks for MS.
These data are important for genetic counselling and for molecular genetic (genome screens, candidate gene analyses) studies.