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The vitamin D receptor Fok I start codon polymorphism and bone mineral density in osteoporotic postmenopausal French women
Author(s) -
Lucotte Gérard,
Mercier Géraldine,
Burckel André
Publication year - 1999
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1034/j.1399-0004.1999.560307.x
Subject(s) - calcitriol receptor , femoral neck , endocrinology , medicine , genotype , bone mineral , osteoporosis , allele , polymorphism (computer science) , gene polymorphism , vitamin d and neurology , bone density , menopause , biology , genetics , gene
This study examined the association between bone mineral density (BMD) and a T/C polymorphism in the first of the two initiation codons in the vitamin D receptor (VDR) gene. The polymorphism was detected using the restriction enzyme Fok I, the F allele indicating absence of the first codon and the f allele its presence. The Fok I genotype was determined in 124 postmenopausal osteoporotic French women who were 45–90 years old. The distribution of Fok I genotypes in the osteoporotics did not differ significantly from that found in a control group. There were no significant differences by Fok I genotype groups in our total sample of osteoporotic women for age, years since menopause, height, weight, and BMD at lumbar spine and femoral neck. However, when only those patients under the age of 75 years are analysed (98 subjects), those with the ff genotype (10% of the population) had a significantly lower BMD at the femoral neck than FF and Ff subjects. This suggests that the ff genotype of the VDR gene correlates with decreased BMD at the femoral neck in French postmenopausal women.