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Autosomal dominant carpal tunnel syndrome
Author(s) -
Stoll C.,
Maitrot D.
Publication year - 1998
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1034/j.1399-0004.1998.5440414.x
Subject(s) - carpal tunnel syndrome , daughter , aunt , cousin , anticipation (artificial intelligence) , medicine , sister , family history , pediatrics , inheritance (genetic algorithm) , sibling , disease , surgery , genetics , pathology , psychology , biology , developmental psychology , gene , history , archaeology , evolutionary biology , artificial intelligence , sociology , anthropology , computer science
Carpal tunnel syndrome is common in adults and is usually sporadic and idiopathic. When carpal tunnel syndrome is inherited, it is often the manifestation of a systemic disease. We report carpal tunnel syndrome in an otherwise healthy woman aged 35 years. Family history reveals that her daughter, her sister and a sister's daughter, an aunt, a first cousin, her father and the paternal grandmother are also affected. The age of onset of the disease in this family was between 9 and 52 years of age. The family in this paper demonstrates an interesting pattern of inheritance with earlier onset of symptoms in subsequent generations, suggestive of anticipation.