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Relationship between airway hyperresponsiveness to mannitol and adenosine monophosphate
Author(s) -
Currie G. P.,
Haggart K.,
Brannan J. D.,
Lee D. K. C.,
Anderson S. D.,
Lipworth B. J.
Publication year - 2003
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1034/j.1398-9995.2003.00226.x
Subject(s) - mannitol , airway hyperresponsiveness , medicine , asthma , adenosine monophosphate , adenosine , methacholine , endocrinology , anesthesia , chemistry , respiratory disease , biochemistry , lung
Background: Assessment of airway hyperresponsiveness (AHR) to indirect bronchoconstrictor stimuli is a useful noninvasive tool in the evaluation of asthma and its treatment. We investigated the putative relationship in AHR between inhaled adenosine monophosphate and mannitol. Methods: Fifteen mild‐to‐moderate atopic asthmatics were evaluated. On two separate screening days, the threshold AMP concentration and threshold mannitol dose to provoke a given fall in FEV 1 were measured. Results: For AMP PC 20 vs. mannitol PD 15 , the Pearsons correlation coefficient was 0.80, P < 0.001. For AMP PC 15 vs. mannitol PD 15 and AMP PC 10 vs. mannitol PD 10 corresponding values were 0.83, P < 0.001 and 0.68, P = 0.005. Conclusions: There was a highly significant association between the threshold concentration of AMP and dose of mannitol causing a given fall in FEV 1 . Further studies are required to evaluate the relationship between inhaled mannitol and other surrogate inflammatory markers.