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The IL1A genotype is associated with nasal polyposis in asthmatic adults
Author(s) -
Karjalainen J.,
JokiErkkilä VP.,
Hulkkonen J.,
Pessi T.,
Nieminen M. M.,
Aromaa A.,
Klaukka T.,
Hurme M.
Publication year - 2003
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1034/j.1398-9995.2003.00118.x
Subject(s) - pathogenesis , asthma , genotype , allele , immunology , medicine , genetic predisposition , polymorphism (computer science) , disease , genetics , biology , gene
Background: Nasal polyposis (NP) is a chronic inflammatory disease often found coexisting with asthma. As this disorder tends to cluster in families, a genetic predisposition has been suggested. Interleukin‐1 (IL‐1) has been proposed to play a role in the pathogenesis of NP. Methods: We analysed the single G‐to‐T base exchange polymorphism in exon 5 at +4845 of the gene encoding IL‐1 α ( IL1A ) and the C‐to‐T base exchange polymorphism at −511 of the gene encoding IL‐1 β ( IL1B ) in a population‐based sample of adult asthma patients ( n = 245). The data were assessed for correlation with data on history of NP and other phenotype‐related characteristics. Results: The prevalence of NP in our study group was 14.3%. The distribution of the IL1A genotype differed significantly between asthmatics with and without NP ( P = 0.005). The risk of NP was markedly increased in allele G homozygous subjects (OR = 2.73; 95%CI = 1.40–5.32). In the case of IL1B we found no significant associations. Asthmatics with NP had more symptoms than others, but lung function and blood eosinophil counts were similar. Conclusions: Our study demonstrates an association of IL1A with NP inasthmatic patients and addresses the role of IL‐1 α as an inflammatory modulator in the pathogenesis of this disease.