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Peripheral blood mononuclear cells from IgE‐ and non‐IgE‐associated allergic atopic eczema/dermatitis syndrome (AEDS) demonstrate increased capacity of generating interleukin‐13 but differ in their potential of synthesizing interferon‐γ
Author(s) -
Simon D.,
Borelli S.,
Braathen L. R.,
Simon H. U.
Publication year - 2002
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1034/j.1398-9995.2002.13506.x
Subject(s) - immunoglobulin e , medicine , immunology , peripheral blood mononuclear cell , atopic dermatitis , pathogenesis , allergy , interleukin 4 , cytokine , antibody , biology , biochemistry , in vitro
A subgroup of patients with allergic atopic eczema/dermatitis syndrome (AEDS) are known to have normal total and specific IgE levels and negative skin prick tests towards common environmental allergens. This form of the disease has been termed non-IgE-associated allergic AEDS. Although allergic mechanisms appear to be important, the pathogenesis of both IgE- and non-IgE-associated forms of the disease is unknown.