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Clinical manifestations of allergy to Anisakis simplex
Author(s) -
Audicana M.,
García M.,
Del Pozo M. D.,
Díez J.,
Muñoz D.,
Fernández E.,
Echenagusia M.,
Fernández de Corres L.,
Ansotegui I. J.,
Moneo I.
Publication year - 2000
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1034/j.1398-9995.2000.03405.x
Subject(s) - medicine , clinical immunology , garcia , anisakis simplex , allergy , humanities , immunology , biology , philosophy , botany , larva
The sea-®sh parasite Anisakis simplex (As) is the causative agent of anisakiasis, or anisakidosis, and induces IgE production. In 1985, Desowitz et al. described a method to detect speci®c IgE against As (1). In 1990, two clinical reports con®rmed the allergenic potential of As (2, 3). In 1994, we observed that As was able to induce type I hypersensitivity as well. After studying a case of anaphylaxis caused by As (4), we reported 28 patients with immediate hypersensitivity developed after ingestion of parasitized ®sh (5), and we now have more than 60 allergic cases. Each case was diagnosed by suggestive anamnesis, positive skin prick tests with three As extracts (frozen, heated, and boiled), speci®c IgE detection in serum (CAP System), and exclusion of ®sh allergy.